Feh, sucks to keep my genetic purity? But I remembered one v. important thing about FO3 you forgot, the soundtrack. A mixture of eerie ambient music and 1950's swing/pop. Hearing the song "Way Back Home" was particularly poignant after doing one very touching quest. One line of the song specifically.

(Oh yeah and the ambient music is just stunning to listen to when wandering around, take Animal Friend so you don't get it interrupted with any of the combat music :P)